A New Aporphine Alkaloid from Litsea glutinosa to Attenuate Palmitate Induced Viability in MIN6 Cells

A new alkaloid called Litsine E (1) and three known aporphine alkaloids (2-4) were isolated from Litsea glutinosa. The structure of the new compound was established using spectroscopic techniques such as HMBC, HSQC, COSY, NOESY, and HRESIMS. Electronic circular dichroism (ECD) calculations were used to estimate its absolute configuration. Subsequently, the newly identified compound was evaluated for its potential to attenuate palmitate-induced viability, demonstrating a significant increase in viability in MIN6 cells.