Supramolecular Nano-Grid Platform to Load and Deliver Liposomes and Exosomes

In general, carriers are designed to deliver pharmaceutical (featuring small drug-molecules) and biopharmaceutical (featuring large-molecule drugs, e.g., antibodies, proteins, etc.) active ingredients and platform that is capable of transporting nanoparticles is rare. Herein, the fabrication of a supramolecular carrier with a nano-grid structure for the entrapment of liposomes and exosomes is reported. The nano-grid particles (NGP) are made of cyclodextrins as elementary units which are widely used to load drugs through host-guest inclusion complexes, whilst its secondary structure further formed the NGP tertiary architectures, enabling the entrapment of nanoparticles. The NGP features stimuli responsiveness, tunable surface charge, and good biocompatibility. The entrapped liposomes in NGP present enhanced distribution in lungs and extended duration of action in mice. And elongated release profiles for over 14 days is obtained for exosomes-making one-of-its-kind unique platform to load and deliver nanoparticles. A supramolecular carrier with nano-grid structure is designed using cyclodextrins as primary units, which is featured with stimuli responsiveness, tunable surface charge, and biocompatibility. Nanoparticles of artificial liposomes and exosomes were successfully anchored in the nano voids within nano-grid, providing liposomes extended duration and enhanced distribution in lungs in mice, and exosomes extremely elongated release profiles to weeks.image (c) 2024 WILEY-VCH GmbH