Virgaricins C and D, new pramanicin analogs produced by Apiospora sp. FKI-8058

So-ichiro Kimura,Yoshihiro Watanabe, Yudai Mikasa,Rei Miyano,Toshiyuki Tokiwa,Kenichi Nonaka,Takuji Nakashima,Yoshihiko Noguchi,Tomoyasu Hirose,Toshiaki Sunazuka,Rei Hokari,Aki Ishiyama,Masato Iwatsuki

The Journal of Antibiotics（2024）

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摘要

Two new pramanicin analogs, named virgaricins C ( 1 ) and D ( 2 ), were discovered by physicochemical screening from a static cultured material of Apiospora sp. FKI-8058. Their structures were elucidated by MS and NMR analyses and chemical derivatization. Compounds 1 and 2 showed moderate antimalarial activity and cytotoxicity.

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