Ovariectomy induces hyperalgesia accompanied by upregulated estrogen receptor α and protein kinase B in the rat spinal cord

Li-Hong Li,Dan-Dan Ling,Hong Lin,Zhe-Chen Wang, Zhi-Rong Sun,Yu-Qiu Zhang,Liu Yang,Jun Zhang,Hong Cao

Physiology & Behavior（2023）

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摘要

•OVX exacerbates formalin-evoked nociceptive behaviors.•OVX induces increased ERα but not ERβ expression in spinal cord.•The spinal AKT is involved in the OVX-induced hyperalgesia.

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关键词

Estradiol,Ovariectomy,Estrogen receptor α,AKT,Spinal cord,Rat

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