Nanoformulations of Chemotherapeutic Activators for cGAS-STING Pathway in Tumor Chemoimmunotherapy

Lingzhi Wang,Zhuo Yu,Jihong Zhang,Jianfeng Guo

Drug Discovery Today（2024）

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摘要

•Chemotherapy drugs that activate the cGAS–STING pathway in tumor cells induce a chemoresponse.•Emerging chemotherapeutic activators broaden the applicability of cGAS–STING therapy.•Nanoformulations potentially conquer delivery barriers of chemotherapeutic activators.•Combinatorial regimens promote efficacy of chemotherapeutic activators to tumors.

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关键词

nanoparticle,DNA-damaging drugs,drug repurposing,immunotherapy,combination therapy

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