Understanding the Dynamics of the Proliferative Phase in Local Burn Wound Healing: A Computational Model.

Understanding the dynamic processes that underlie burn wound healing is a complex endeavor that requires advanced computational approaches. The proliferative phase in burn wounds is critical for the closure of the burn wound. We present a novel model that uses a set of coupled ordinary differential equations that predict intricate interactions between different cell types, cytokines, growth factors, and proteins during the proliferative phase of wound healing after burn injury. We simulated the model for 30 weeks and were able to predict cell and molecular dynamics in this intricate phase of burn wound healing. We achieved biologically sensible results and were able to identify fibroblasts, myofibroblasts, and collagen types III and I as crucial parameters that drive the proliferative phase in burn wounds.