Correlation between serum biomarkers, brain volume, and retinal neuronal loss in early-onset Alzheimer’s disease

Purpose To compare the peripapillary retinal nerve fiber layer (pRNFL), retinal nerve fiber layer (RNFL), and ganglion cell complex (GCC) thickness measurement in early-onset Alzheimer’s disease (EOAD) and controls using spectral domain optical coherence tomography (SD-OCT). We also assessed the relationship between SD-OCT measurements and cognitive measures, serum biomarkers for Alzheimer’s disease (AD), and cerebral microstructural volume. Methods pRNFL, RNFL, and GCC thicknesses were measured in 43 EOAD and 42 controls using SD-OCT. Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE) were used to assess cognitive status, magnetic resonance imaging (MRI) tool was used to quantify cerebral microstructural volume, and serum biomarkers were quantified from peripheral blood. Results EOAD patients had thinner pRNFL ( P < 0.001), RNFL ( P = 0.008), and GCC ( P = 0.018) thicknesses compared to controls after adjusting for multiple factors. pRNFL thickness correlated ( P = 0.016) with serum t-tau level. Serum Aβ42 ( P < 0.05) concentration correlated with RNFL thickness. Importantly, occipital lobe volume ( P = 0.010) correlated with GCC thicknesses in EOAD patients. Conclusion Our findings suggest that retinal thickness may be useful markers for assessing neurodegenerative process in EOAD.