First-Hit SETBP1 Mutations Cause a Myeloproliferative Disorder with Bone Marrow Fibrosis Ilaria Crespiatico , Mattia Zaghi , Cristina Mastini , Deborah D'Aliberti , Mario Mauri , Carl Mirko Mercado , Diletta Fontana , Silvia Spinelli , Valentina Crippa , Elena Inzoli , Beatrice Manghisi , Ivan Civettini , Daniele Ramazzotti , Valentina Fabiola Ilenia Lavoro , Michele Gengotti , Virginia Brambilla , Andrea Aroldi , Federica Banfi , Cristiana Barone , Roberto Orsenigo , Ludovica Riera , Mara Riminucci , Alessandro Corsi , Massimo Breccia , Alessandro Morotti , Daniela Cilloni , Aldo Roccaro , Antonio Sacco , Fabio Stagno , Marta Serafini , Federica Mottadelli , Giovanni Cazzaniga , Fabio Pagni , Roberto Chiarle , Emanuele Azzoni , Alessandro Sessa , Carlo Gambacorti-Passerini , Elena Maria Elli , Luca Mologni , Rocco Piazza BLOOD（2023）
摘要
-SETBP1 mutations, acting as a first-hit/early event, drive an aggressive myelofibrosis-like myeloproliferative disorder-SETBP1 mutations discriminate between two subtypes of Triple-Negative Myelofibrosis, with different genetic landscape and aggressiveness.
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