Intranasal irbesartan reverts cognitive decline and activates the PI3K/AKT pathway in an LPS-induced neuroinflammation mice model

Filipa Gouveia,Carla Fonseca,Ana Silva,Antoni Camins,M. Teresa Cruz,Miren Ettcheto,Ana Fortuna

International Immunopharmacology（2024）

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摘要

•Multiple intranasal administrations of irbesartan prevent LPS-induced cognitive decline.•Irbesartan increases spine density.•Renin angiotensin system regulates the PI3K/AKT pathway.

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关键词

Neuroinflammation,Renin angiotensin system,Alzheimer’s disease,Irbesartan,Intranasal

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