The Prognostic Significance of Vitamin D Deficiency in Korean Patients With Multiple Myeloma

Vitamin D deficiency in Asian patients with multiple myeloma has yet to be assessed for its prognostic importance. We analyzed 98 patients of newly diagnosed multiple myeloma. The results showed that vitamin D deficiency is a prognostic factor in patients with multiple myeloma. Background: Vitamin D deficiency is relatively common among patients with multiple myeloma. The prognostic significance of vitamin D deficiency in Asian patients with multiple myeloma remains unevaluated. This study aimed to assess the prognostic value of vitamin D levels in this Korean patient population. Methods: From September 2017 to May 2020, 98 patients were enrolled in the study. Vitamin D deficiency was defined as 25-hydroxyvitamin D level of less than 10 ng/mL. Results: Thirty-six patients (36.7%) had vitamin D deficiency. These patients had significantly lower 2-year progression-free survival rates (44.8% vs. 66.9%, P = .008) and overall survival (OS) rates (2-year OS 47.2% vs. 74.2%, P = .024) compared with those without deficiency. Furthermore, patients who received vitamin D supplementation showed a trend towards improved OS compared with those who did not, with a 2-year OS rate of 51.9% vs. 33.3% ( P = .14). Conclusion: These findings suggest that vitamin D levels are a significant prognostic factor in patients with multiple myeloma.