Investigating heterogeneous PSMA ligand uptake inside parotid glands
arxiv(2024)
摘要
The purpose was to investigate the spatial heterogeneity of prostate-specific
membrane antigen (PSMA) positron emission tomography (PET) uptake within
parotid glands. We aim to quantify patterns in well-defined regions to
facilitate further investigations. Furthermore, we investigate whether uptake
is correlated with computed tomography (CT) texture features. Parotid glands
from [18F]DCFPyL PSMA PET/CT images of 30 prostate cancer patients were
analyzed. Thresholding was used to define high-uptake regions, and uptake
statistics were computed within various divisions. Spearman's rank correlation
coefficient was calculated between PSMA PET uptake and the Grey Level Run
Length Matrix (GLRLM) using a long and short run length emphasis (GLRLML and
GLRLMS) in subregions of parotid glands. PSMA PET uptake was significantly
higher (p < 0.001) in lateral/posterior regions of the glands than
anterior/medial regions. Maximum uptake was found in the lateral half of
parotid glands in 50 out of 60 glands. The difference in SUV between parotid
halves is greatest when parotids are divided by a plane separating the
anterior/medial and posterior/lateral halves symmetrically. PSMA PET uptake was
significantly correlated with CT GLRLML (p < 0.001), and anti-correlated with
CT GLRLMS (p < 0.001). Uptake of PSMA PET is heterogeneous within parotid
glands, with uptake biased towards lateral and posterior regions. Uptake
patterns within parotid glands were found to be strongly correlated with CT
texture features, suggesting the possible future use of CT texture features as
a proxy for inferring PSMA PET uptake in salivary glands.
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