Groebke Blackburn Bienaymé-mediated multi-component synthesis of selective HDAC6 inhibitors with anti-inflammatory properties

Fabian B. Kraft,Jana Enns, Irina Honin, Jonas Engelhardt,Andrea Schöler,Shannon T. Smith,Jens Meiler, Linda Schäker-Hübner,Günther Weindl,Finn K. Hansen

Bioorganic Chemistry（2024）

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摘要

•Novel HDACi were synthesized using a one-pot multi-component protocol as key step.•Compounds 8k and 8m were identified as highly selective HDAC6 inhibitors.•8k and 8m showed significant inhibition of LPS-induced IL1B mRNA expression.

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