Clinicopathological Significance and Expression Pattern of Bcl2 in Breast Cancer: A Comprehensive in silico and in vitro Study

•This study reflects the pivotal role and prognostic consequence of Bcl2 in BC pathogenesis.•Bcl2 was selected as a potent target for this study, as its overexpression accelerates the Breast tumorigenesis.•In-vitro and in-silico outcomes reveal that Bcl2 enhance tumorigenesis and exhibit worse clinical outcomes.•Targeting BCL2 in combination with other therapeutic drugs will dramatically improve Breast cancer patients' responses to therapy and prevent the emergence of chemoresistance.•Bcl2 acts as a prognostic marker and antagonizing it could be one of the potential therapeutic strategies to treat BC.