Late Subacute Cerebral Hematoma Mimicking a Metastasis on PSMA PET/CT

A 64-year-old man with history of prostate cancer was found to have rising prostate-specific antigen after radical prostatectomy. F-18-DCFPyL PET/CT demonstrated a prostate-specific membrane antigen-avid brain lesion in the left frontal lobe and no other findings to account for rising prostate-specific antigen. Brain MRI demonstrated a small intraparenchymal hematoma with late subacute features in this location. The patient reported a seizure 3 weeks before but was otherwise asymptomatic, and neurologic examination was normal. Follow-up MRI demonstrated gradual decrease in size of the hematoma without treatment.