Enzyme‐Triggered Intestine‐Specific Targeting Adhesive Platform for Universal Oral Drug Delivery (Adv. Healthcare Mater. 27/2023)

Enzyme-Triggered Adhesives In article 2301033, Giovanni Traverso and co-workers develop an oral sandwiched pill with in situ gelling systems gelled based on enzyme catalyzed crosslinking reactions, which undergo mild conditions, tunable gelation rate, and tough mechanical properties by a simple mixing to deliver clinically-relevant doses of hydrophilic and hydrophobic drugs in a large animal model, with a sustained half life and Tmax compared to conventional pills. This work is seen as a transformative step in drug delivery research that ushers in a new era of oral sustained drug delivery: The invention can not only be used to orally deliver drugs to optimize drugs pharmacokinetics after oral administration, but also can be used in gastrointestinal (GI) diagnoses application to ensure the diagnostic device stays in the GI tract for enough time.