Information-reference system on human brain development

BACKGROUND: The information about intrauterine maturation of the human brain is fragmentary, which make it necessary to systematize these data in the form of an information reference system. A modern solution would be the creation of a multimodal digital atlas, which would combine images of the developing brain at the macro-morphological, tissue, and cellular levels. AIM: The aim of this study was to create a prototype of an informational reference system on human brain development, incorporating a digital multimodal atlas with the ability to view specific brain regions. METHODS: The creation of a prototype informational reference system on human brain prenatal morphogenesis involved the following stages: researching the subject area, developing an informational model, defining automation tasks and functionality of the information system, selecting hardware and software tools, testing, and analyzing results. RESULTS: Based on the analysis, a prototype of the informational reference system "Human Brain Development Atlas" has been developed, consisting of three main blocks for each ontogenetic stage: 1) "Description of Brain Development Stage": This section includes a macroscopic description of brain structure, an overview of key morphogenetic events, and galleries with hematoxylin and eosin, Nissl, and Mallory stained sections. 2) "Reference Atlases": This module contains annotated maps of brain sections at different stages of prenatal ontogenesis. 3) "Immunohistochemical Atlases": This module provides data on the developmental translational profile of brain cells. Currently, some of the materials are already available on the project website: https://brainmorphology.science/ru/ CONCLUSION: Modern information technologies can be used for data collection and processing on human brain prenatal morphogenesis. The creation of an informational reference system on human brain prenatal morphogenesis can contribute to the development of new methods for early diagnosis and treatment of various nervous system disorders.