IGF2BP3 Enhances the Growth of Hepatocellular Carcinoma Tumors by Regulating the Properties of Macrophages and CD8⁺ T Cells in the Tumor Microenvironment

Likun Ma, Jiayu Jiang,Si Qin,Chong Chen, Zhiqing Duan

Journal of clinical and translational hepatology（2023）

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摘要

Background and AimsOverexpression of IGF2BP3 is associated with the prognosis of hepatocellular carcinoma (HCC). However, its role in regulating tumor immune microenvironment (TME) is not well characterized. Here, we investigated the effects of IGF2BP3 on macrophages and CD8+ T cells within the TME of HCC.

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hepatocellular carcinoma,hepatocellular carcinoma tumors,tumors microenvironment

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IGF2BP3 Enhances the Growth of Hepatocellular Carcinoma Tumors by Regulating the Properties of Macrophages and CD8+ T Cells in the Tumor Microenvironment

IGF2BP3 Enhances the Growth of Hepatocellular Carcinoma Tumors by Regulating the Properties of Macrophages and CD8⁺ T Cells in the Tumor Microenvironment