Glutathione restoration: a sword to combat skeletal muscle stem cell aging

In a recent study published in Cell Metabolism, Thomas A. Rando and colleagues reported a critical role of dysregulated glutathione (GSH) metabolism in driving the aging process of skeletal muscle stem cells (MuSCs), uncovering a novel mechanism underlying the divergent responses of quiescent stem cells to environmental stressors with age, thus providing a potentially accessible target to alleviate age-associated skeletal muscle degeneration.