Regulation of Postnatal Cardiomyocyte Maturation by an RNA Splicing Regulator RBFox1

HomeCirculationVol. 148, No. 16Regulation of Postnatal Cardiomyocyte Maturation by an RNA Splicing Regulator RBFox1 No AccessResearch ArticleRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessResearch ArticleRequest AccessFull TextRegulation of Postnatal Cardiomyocyte Maturation by an RNA Splicing Regulator RBFox1 Jijun Huang, Josh Z. Lee, Christoph D. Rau, Arash Pezhouman, Tomohiro Yokota, Hiromi Miwa, Matthew Feldman, Tsz Kin Kong, Ziyue Yang, Woan Ting Tay, Ivan Pushkarsky, Kyungsoo Kim, Shan S. Parikh, Shreya Udani, Boon Seng Soh, Chen Gao, Linsey Stiles, Orian S. Shirihai, Bjorn C. Knollmann, Reza Ardehali, Dino Di Carlo and Yibin Wang Jijun HuangJijun Huang Correspondence to: Yibin Wang, PhD, Duke-NUS Medical School, 8 College Rd, Level 8, Singapore 169857, Singapore. Email E-mail Address: [email protected] https://orcid.org/0000-0002-5520-193X Cardiovascular Laboratory, Division of Molecular Medicine, Department of Anesthesiology and Perioperative Medicine (J.H., J.Z.L., C.D.R., T.Y., T.K.K., C.G., Y.W.), University of California, Los Angeles. Division of Endocrinology (J.H.), University of California, Los Angeles. *J. Huang and J.Z. Lee contributed equally. Search for more papers by this author , Josh Z. LeeJosh Z. Lee Cardiovascular Laboratory, Division of Molecular Medicine, Department of Anesthesiology and Perioperative Medicine (J.H., J.Z.L., C.D.R., T.Y., T.K.K., C.G., Y.W.), University of California, Los Angeles. *J. Huang and J.Z. Lee contributed equally. Search for more papers by this author , Christoph D. RauChristoph D. Rau Cardiovascular Laboratory, Division of Molecular Medicine, Department of Anesthesiology and Perioperative Medicine (J.H., J.Z.L., C.D.R., T.Y., T.K.K., C.G., Y.W.), University of California, Los Angeles. Department of Genetics and Computational Medicine, University of North Carolina, Chapel Hill (C.D.R.). Search for more papers by this author , Arash PezhoumanArash Pezhouman https://orcid.org/0000-0001-9106-7136 Division of Cardiology, Department of Medicine (A.P., T.Y., R.A.), University of California, Los Angeles. Section of Cardiology, Department of Internal Medicine, Baylor College of Medicine, Houston, TX (A.P., R.A.). Search for more papers by this author , Tomohiro YokotaTomohiro Yokota Cardiovascular Laboratory, Division of Molecular Medicine, Department of Anesthesiology and Perioperative Medicine (J.H., J.Z.L., C.D.R., T.Y., T.K.K., C.G., Y.W.), University of California, Los Angeles. Division of Cardiology, Department of Medicine (A.P., T.Y., R.A.), University of California, Los Angeles. Department of Medicine, Greater Los Angeles VA Healthcare System, CA (T.Y.). Search for more papers by this author , Hiromi MiwaHiromi Miwa Department of Bioengineering, Samueli School of Engineering (H.M., S.U., D.D.), University of California, Los Angeles. Search for more papers by this author , Matthew FeldmanMatthew Feldman School of Medicine, Meharry Medical College, Nashville, TN (M.F.). Search for more papers by this author , Tsz Kin KongTsz Kin Kong Cardiovascular Laboratory, Division of Molecular Medicine, Department of Anesthesiology and Perioperative Medicine (J.H., J.Z.L., C.D.R., T.Y., T.K.K., C.G., Y.W.), University of California, Los Angeles. Search for more papers by this author , Ziyue YangZiyue Yang Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX (Z.Y.). Search for more papers by this author , Woan Ting TayWoan Ting Tay https://orcid.org/0000-0002-4845-287X Signature Research Program of Cardiovascular and Metabolic Diseases, Duke-NUS Medical School, Singapore (W.T.T., Y.W.). Search for more papers by this author , Ivan PushkarskyIvan Pushkarsky Forcyte Biotechnologies, Inc, Los Angeles, CA (I.P.). Search for more papers by this author , Kyungsoo KimKyungsoo Kim https://orcid.org/0000-0003-2869-0659 Vanderbilt Center for Arrhythmia Research and Therapeutics, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN (K.K., S.S.P., B.C.K.). Search for more papers by this author , Shan S. ParikhShan S. Parikh https://orcid.org/0000-0003-1806-9199 Vanderbilt Center for Arrhythmia Research and Therapeutics, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN (K.K., S.S.P., B.C.K.). Search for more papers by this author , Shreya UdaniShreya Udani Signature Research Program of Cardiovascular and Metabolic Diseases, Duke-NUS Medical School, Singapore (W.T.T., Y.W.). Search for more papers by this author , Boon Seng SohBoon Seng Soh https://orcid.org/0000-0001-9134-3081 Institute of Molecular and Cell Biology, The Agency for Science, Technology and Research (A*STAR), Singapore (B.S.S.). Search for more papers by this author , Chen GaoChen Gao Cardiovascular Laboratory, Division of Molecular Medicine, Department of Anesthesiology and Perioperative Medicine (J.H., J.Z.L., C.D.R., T.Y., T.K.K., C.G., Y.W.), University of California, Los Angeles. Department of Pharmacology and System Physiology, University of Cincinnati, OH (C.G.). Search for more papers by this author , Linsey StilesLinsey Stiles Department of Medicine, David Geffen School of Medicine (L.S., O.S.S.), University of California, Los Angeles. Search for more papers by this author , Orian S. ShirihaiOrian S. Shirihai Department of Medicine, David Geffen School of Medicine (L.S., O.S.S.), University of California, Los Angeles. Search for more papers by this author , Bjorn C. KnollmannBjorn C. Knollmann https://orcid.org/0000-0003-4956-9735 Vanderbilt Center for Arrhythmia Research and Therapeutics, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN (K.K., S.S.P., B.C.K.). Search for more papers by this author , Reza ArdehaliReza Ardehali https://orcid.org/0000-0003-1318-4016 Division of Cardiology, Department of Medicine (A.P., T.Y., R.A.), University of California, Los Angeles. Section of Cardiology, Department of Internal Medicine, Baylor College of Medicine, Houston, TX (A.P., R.A.). Search for more papers by this author , Dino Di CarloDino Di Carlo Department of Bioengineering, Samueli School of Engineering (H.M., S.U., D.D.), University of California, Los Angeles. Search for more papers by this author and Yibin WangYibin Wang https://orcid.org/0000-0003-0852-0767 Cardiovascular Laboratory, Division of Molecular Medicine, Department of Anesthesiology and Perioperative Medicine (J.H., J.Z.L., C.D.R., T.Y., T.K.K., C.G., Y.W.), University of California, Los Angeles. Signature Research Program of Cardiovascular and Metabolic Diseases, Duke-NUS Medical School, Singapore (W.T.T., Y.W.). Search for more papers by this author Originally published16 Oct 2023https://doi.org/10.1161/CIRCULATIONAHA.122.061602Circulation. 2023;148:1263–1266Footnotes*J. Huang and J.Z. Lee contributed equally.For Sources of Funding and Disclosures, see page 1266.Circulation is available at www.ahajournals.org/journal/circCorrespondence to: Yibin Wang, PhD, Duke-NUS Medical School, 8 College Rd, Level 8, Singapore 169857, Singapore. Email yibinwang@duke-nus.edu.sgREFERENCES1. Karbassi E, Fenix A, Marchiano S, Muraoka N, Nakamura K, Yang X, Murry CE. Cardiomyocyte maturation: advances in knowledge and implications for regenerative medicine.Nat Rev Cardiol. 2020; 17:341–359. doi: 10.1038/s41569-019-0331-xCrossrefMedlineGoogle Scholar2. Guo Y, Pu WT. Cardiomyocyte maturation: new phase in development.Circ Res. 2020; 126:1086–1106. doi: 10.1161/CIRCRESAHA.119.315862LinkGoogle Scholar3. Gao C, Ren S, Lee JH, Qiu J, Chapski DJ, Rau CD, Zhou Y, Abdellatif M, Nakano A, Vondriska TM, et al. RBFox1-mediated RNA splicing regulates cardiac hypertrophy and heart failure.J Clin Invest. 2016; 126:195–206. doi: 10.1172/JCI84015CrossrefMedlineGoogle Scholar4. Wang Y, Yao F, Wang L, Li Z, Ren Z, Li D, Zhang M, Han L, Wang SQ, Zhou B, et al. Single-cell analysis of murine fibroblasts identifies neonatal to adult switching that regulates cardiomyocyte maturation.Nat Commun. 2020; 11:2585. doi: 10.1038/s41467-020-16204-wCrossrefMedlineGoogle Scholar5. Pushkarsky I. FLECS technology for high-throughput single-cell force biology and screening.Assay Drug Dev Technol. 2018; 16:7–11. doi: 10.1089/adt.2017.825CrossrefMedlineGoogle Scholar eLetters(0)eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. Authors of the article cited in the comment will be invited to reply, as appropriate.Comments and feedback on AHA/ASA Scientific Statements and Guidelines should be directed to the AHA/ASA Manuscript Oversight Committee via its Correspondence page.Sign In to Submit a Response to This Article Previous Back to top Next FiguresReferencesRelatedDetails October 17, 2023Vol 148, Issue 16 Advertisement Article InformationMetrics © 2023 American Heart Association, Inc.https://doi.org/10.1161/CIRCULATIONAHA.122.061602PMID: 37844148 Originally publishedOctober 16, 2023 KeywordsRNA, messengersequence analysis, RNAmyocytes, cardiacPDF download Advertisement SubjectsMechanismsMyocardial BiologyMyocardial RegenerationStem Cells