DEP-1 a Novel Modulator of Energy Metabolism

Obesity is associated with insulin and leptin resistance, which affects peripheral tissues as well as the brain. The novel density-enhanced phosphatase-1 (DEP-1), is a known negative modulator of insulin and leptin signaling. Intriguingly, diet-induced obese mice have increased DEP-1 expression in metabolic sensitive tissues, including the brain. In this study, the regulation of DEP-1-dependent metabolic effects was investigated in vitro and in vivo.