NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer

(Cell Metabolism 35, 487–503.e1–e7; March 7, 2023) In the originally published version of this article, a panel was mistakenly duplicated in Figure 4C. The image was duplicated when we were assembling the figure. This error has been corrected and does not affect the conclusions of the paper. The authors apologize for any confusion that this error may have caused.Figure 4CNRF2 induces NADH-reductive stress in KEAP1-dependent cells (original)View Large Image Figure ViewerDownload Hi-res image Download (PPT) NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancerWeiss-Sadan et al.Cell MetabolismFebruary 24, 2023In BriefA subset of lung cancer cell lines is sensitive to activation of the transcription factor NRF2. The metabolic state of a cancer cell dictates sensitivity to NRF2, whose activation results in a NADH/NAD+ imbalance. As a result, the blockade of mitochondrial Complex I is a synthetic lethality in NRF2-activated lung cancers. Full-Text PDF