Abstract 15511: Sex-Specific Trends in Obesity-Attributable Atrial Fibrillation in the United States

Introduction: The prevalence of atrial fibrillation (AF) has significantly increased in the United States over the past 2 decades. Obesity is a major risk factor for AF, and the association between obesity and AF may vary by sex. We sought to investigate sex-specific trends in obesity-attributable AF in the US Methods: We used data from the 2019 Global Burden of Disease Study to determine changes in age-standardized AF disability-adjusted life years (DALYs) and mortality in the US between 1990 and 2019. We examined the trends in the contribution of obesity to AF mortality and DALYs by sex. Results: Between 1990 and 2019, age-standardized AF DALYs increased by 13% in males (181 to 205 per 100K) and by 15% in females (110 to 126 per 100K). Age-adjusted AF mortality increased by 22% in males (4.9 to 6.0 per 100K) and by 26% in females (3.5 to 4.4 per 100K). Overall, obesity contributed to higher percentage of AF in females compared with males. Between 1990 and 2019, the percentage of obesity-attributed AF DALYs increased in females (27% to 34%) and males (21% to 31%). The percentage of obesity-attributed AF deaths increased both in females (25% to 32%) and males (18% to 28%) between 1990 and 2019, figure. Conclusion: AF morbidity and mortality showed a disproportionate increase among females compared with males in the US over the past 3 decades. Obesity disproportionately contributes to AF morbidity and mortality among females compared with males.