Insulin directly regulates the circadian clock in adipose tissue

N Tuvia,O Pivovarova-Ramich,V Murahovschi,S Luck,A Grudziecki, Ost AC,M Kruse, Nikiforova VJ,M Osterhoff, P Gottmann, O Gogebakan,C Sticht,N Gretz,M Schupp,A Schurmann,N Rudovich,Pfeiffer AFH,A Kramer

Yearbook of pediatric endocrinology（2022）

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摘要

Brief Summary: This study analyzed gene expression in subcutaneous adipose tissue samples of adults with obesity collected before and after the hyperinsulinemiceuglycemic clamp or control saline infusion. They demonstrate that insulin regulates clock genes in both murine and human adipocytes and adipose-derived stem cells (ASCs).

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circadian clock,insulin

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