PE-123 : Characteristics of Cholangiocarcinoma in India - Experience from a Tertiary Care Centre

Aims: Cholangiocarcinoma is a rare disease in India with no major studies published till date due to paucity of epidemiological and surgical data. The aim was to evaluate the clinical profile of patients presenting with intrahepatic and peri-hilar cholangiocarcinoma to a tertiary care cancer centre. Methods: All patients diagnosed with intrahepatic cholangiocarcinoma (IHCC) and perihilar cholangiocarcinoma (PHCC) at Tata Memorial Hospital, Mumbai, between January 2012 to July 2016 were retrospectively analyzed. Results: A total of 726 patients were evaluated of which 273 patients had IHCC and 358 were diagnosed with PHCC. The median age of presentation for IHCC and PHCC were 57yrs and 56.7yrs. Majority of patients were males - 59% for IHCC and 56.7% for PHCC. Commonest symptoms were pain in abdomen and jaundice with average duration of symptoms being 8 weeks (IHCC) and 9.4 weeks (PHCC) respectively. Most patients with IHCC had metastatic disease (184, 67.9%) on presentation. For patients with PHCC, 50.8% (182) had localized disease, 17% (61) had locally advanced and 24.3% (87) were metastatic. Chemotherapy with palliative intent was offered to 144 patients with IHCC and 60 patients with PHCC. Surgery or chemoradiotherapy could be offered to only 59 patients with IHCC and 128 patients of PHCC. 56 patients with IHCC and 136 of PHCC patients did not take treatment due to socioeconomic reasons. Conclusions: With less than 15% patients receiving surgery, awareness and early referral with centralization is required to detect disease at a stage where treatment can offer a meaningful survival.