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Use of pyridazinediones for tuneable and reversible covalent cysteine modification applied to peptides, proteins and hydrogels

Léa N. C. Rochet,Calise Bahou,Jonathan P. Wojciechowski,Ilias Koutsopetras,Phyllida Britton,Richard J. Spears,Ioanna A. Thanasi,Baihao Shao, Lei Zhong,Dejan‐Krešimir Bučar,Abil E. Aliev,Michael J. Porter,Molly M. Stevens,James R. Baker,Vijay Chudasama

Chemical Science（2023）

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摘要
Substituted pyridazinediones (PDs) enable reversible and tuneable cysteine modification with exemplification on peptides, proteins and hydrogels.
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关键词
reversible covalent cysteine modification,pyridazinediones,peptides,hydrogels
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