Regulation of Trib2 by an E2F1-C/EBPα feedback loop in AML cell proliferation

Loveena Rishi,Maura Hannon,Mara Salomè,Marie Sigurd Hasemann,Anne-Katrine Frank,Joana Campos,Jennifer Timoney,Caitríona O’Connor,Mary R. Cahill,Bo T. Porse,Karen Keeshan

Blood（2014）

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摘要

Key Points E2F1 regulates Trib2 expression and C/EBPα modulates E2F1-induced Trib2 activity at the granulocyte macrophage progenitor stage. Pharmacological inhibition of the cell cycle resulting in a block in E2F1 or Trib2 knockdown abrogates AML cell proliferation.

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关键词

trib2,cell proliferation,e2f1-c/ebpα feedback loop

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