One‐Pot Controllable Assembly of a Baicalin‐Condensed Aptamer Nanodrug for Synergistic Anti‐Obesity (Small 6/2023)

Baicalin-Condensed Aptamer Nanodrugs Polymerase chain reaction (PCR)-driven DNA micro-nano-flowers are used to construct a nanosized baicalin-compressed-aptamer-nanodrug (bcaND) via one-pot assembly. The tailored Adipo-8 (tAdi-8) overhang in the PCR amplicon, like an arrow, displays anti-obesity targeting activity, while the baicalin loaded in the bcaND plays a three-fold role as a lipid-lowering factor, bcaND size compressor, and uncoupling protein-1 (UCP1)-raised thermogenic activator. More details can be found in article number 2205933 by Wentao Xu and co-workers.