Impact of polyethylene glycol molar mass and structural isomer of alcohol on the solubility and dissolution enhancement of mesalazine
FLUID PHASE EQUILIBRIA(2024)
摘要
This work reports the solubility of mesalazine (5-ASA) in mole fraction terms (x(1,T)) in mono-solvents of polyethylene glycol (PEG) 400, 1-propanol and 2-propanol along with their binary mixtures in different mass fractions of PEG 400 at 293.15-313.15 K and atmospheric pressure which measured experimentally by a shake-flask technique. The solubility of 5-ASA in these mixtures not only enhances with enhancing temperature, but also raises with raising PEG's mass fraction. Effect of PEG molar mass on the solubility of 5-ASA was also estimated by measuring its solubility in PEG 200 or 600 + 1- or 2-propanol mixtures at 298.15 K. Upon the same temperature and mass fraction of PEGs, the upward trend of 5-ASA mole fractions was: PEG 600 + 1-propanol > PEG 600 + 2propanol > PEG 400 + 1-propanol > PEG 400 + 2-propanol > PEG 200 + 1-propanol > PEG 200 + 2-propanol indicating, the binary mixtures containing a high molar mass of PEG and 1-propanol with a hydroxyl group attached to carbon number 1 had a more solubilization power. Then, the experimental mole fractions were modelled by some cosolvency and activity coefficient models, and the model parameters were regressed. The back-computed mole fractions of 5-ASA by cosolvency models presented a better agreement with the experimental data than that of activity models and Jouyban-Acree model had the best performance (low overall average percentage deviation of 6.1 %). By means of enthalpy-entropy compensation analysis, non-linear Delta H-sol(degrees) against Delta(sol)G(degrees) compensation plots with positive and negative slopes were achieved as a consequent of increasing 5-ASA solvation by PEG molecules and the solvent-structure loosing, respectively.
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关键词
Mesalazine solubility,PEG molar mass,Cosolvency models,Activity coefficient,Thermodynamic functions,1-or 2-propanol
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