PVB exerts anti-inflammatory effects by inhibiting the activation of MAPK and NF-κB signaling pathways and ROS generation in neutrophils

Jiafu Ouyang,Yinghao Hong,Yantong Wan, Xiangyi He, Bingxuan Geng, Xinxing Yang,Jing Xiang,Junwei Cai,Zhenhua Zeng,Zhifeng Liu,Na Peng,Yong Jiang,Jinghua Liu

International immunopharmacology（2024）

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摘要

•PVB treatment either before or after LPS stimulation attenuated IL-1β and TNF-α expression in murine neutrophils.•PVB inhibited the phosphorylation of ERK, JNK, and IκBα in LPS-stimulated murine neutrophils.•PVB reduced ROS levels via regulation of NADPH oxidase 2 (NOX2) activity.•PVB attenuated IL-1β, TNF-α, IL-6, CXCL1 production in both LPS-stimulated LDNs and NDNs isolated from septic patients.

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关键词

Sepsis,Neutrophil,Pinaverium bromide,ROS,NADPH oxidase 2,Cytokine

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