Long non-coding RNAs H19 and NKILA are associated with the risk of death and lacunar stroke in the elderly population

Tetiana Lapikova-Bryhinska,Stefano Ministrini,Yustina M. Puspitasari,Simon Kraler, Shafeeq Ahmed Mohamed,Sarah Costantino,Francesco Paneni,Michael Khetsuriani,Susan Bengs,Luca Liberale,Fabrizio Montecucco, Wolfgang Krampla,Peter Riederer,Margareta Hinterberger,Peter Fischer,Thomas F. Lüscher,Edna Grünblatt,Alexander Akhmedov,Giovanni G. Camici

European Journal of Internal Medicine（2023）

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摘要

•In a population of non-institutionalized 75 years-old subjects, lncRNA H19 predicts all-cause mortality over a follow-up of 14 years.•lncRNA H19 is differentially expressed in males and females, and it is a possible feature of sex differences in lifespan.•low-levels of lncRNA NKILA are associated with an increased risk of lacunar stroke, detected by magnetic resonance, over a follow-up of 7.5 years.

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关键词

Aging,Stroke,Long non-coding RNAs,Oxidative stress,Inflammation,Vascular dysfunction,Neuronal plasticity

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