Therapeutic Potential of Cannabidiol and Cannabigerol in Fracture Healing.

Journal of Bone and Mineral ResearchEarly View Letter to the Editor Therapeutic Potential of Cannabidiol and Cannabigerol in Fracture Healing Yankel Gabet, Corresponding Author Yankel Gabet [email protected] Tel Aviv University School of Medicine – Anatomy & Anthropology, Tel Aviv, Israel[email protected]Search for more papers by this author Yankel Gabet, Corresponding Author Yankel Gabet [email protected] Tel Aviv University School of Medicine – Anatomy & Anthropology, Tel Aviv, Israel[email protected]Search for more papers by this author First published: 17 November 2023 https://doi.org/10.1002/jbmr.4934Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. References 1Khajuria DK, Karuppagounder V, Nowak I, et al. Cannabidiol and cannabigerol, nonpsychotropic cannabinoids, as analgesics that effectively manage bone fracture pain and promote healing in mice. J Bone Miner Res. 2023; 20: 42. 2Russo EB. Cannabidiol claims and misconceptions. Trends Pharmacol Sci. 2017; 38(3): 198–201. 3Amstutz K, Schwark WS, Zakharov A, et al. Single dose and chronic oral administration of cannabigerol and cannabigerolic acid-rich hemp extract in fed and fasted dogs: physiological effect and pharmacokinetic evaluation. J Vet Pharmacol Ther. 2022; 45(3): 245–254. 4Polanska HH, Petrlakova K, Papouskova B, et al. Safety assessment and redox status in rats after chronic exposure to cannabidiol and cannabigerol. Toxicology. 2023; 488:153460. 5Kulpa J, Eglit G, Hill ML, et al. Serum markers of bone turnover following controlled administration of two medical cannabis products in healthy adults. Cannabis Cannabinoid Res. 2022 Nov 8. https://doi.org/10.1089/can.2022.0181. 6Kulpa J, Harrison A, Rudolph L, et al. Oral cannabidiol treatment in two postmenopausal women with osteopenia: a case series. Cannabis Cannabinoid Res. 2023; 8(S1): S83–S89. 7Schmuhl E, Ramer R, Salamon A, Peters K, Hinz B. Increase of mesenchymal stem cell migration by cannabidiol via activation of p42/44 MAPK. Biochem Pharmacol. 2014; 87(3): 489–501. 8Kogan NM, Melamed E, Wasserman E, et al. Cannabidiol, a major non-psychotropic cannabis constituent, enhances fracture healing and stimulates lysyl hydroxylase activity in osteoblasts. J Bone Miner Res. 2015; 30(10): 1905–1913. Early ViewOnline Version of Record before inclusion in an issue ReferencesRelatedInformation