Intrinsic RNA-targeting activity limits the applicability of CRISPR-Cas13
NATURE BIOMEDICAL ENGINEERING（2024）
摘要
We revealed that the RNA-targeting activity of the Cas13 family of nucleases allows them to directly target endogenous RNA in mammalian cells. Such activity limits the usage of lentiviral Cas13 systems, and suggests a need for caution when applying Cas13-based systems.
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