Simulation of GAA-NW-TFET Biosensor with Cluster Charge Probes for Target Biomolecule Detection

This study introduces and simulates a Gate-All-Around Nanowire Tunnel Field Effect Transistor (GAA-NW-TFET) biosensor for biomolecule detection. The proposed silicon-based device employs a cluster of charge probes to identify the target biomolecule. The biomolecules, modeled as charged particles within the electrolyte layer positioned on top of the insulating layer, constitute the focus of our investigation. The central aspect of our study involves evaluating how the spatial arrangement of these target biomolecules affects the biosensor's sensitivity. Our analysis is conducted using Silvaco ATLAS TCAD. The simulation result shows an impressive I-on/I-off sensitivity factor of up to 2.95 x 10(10) for the GAA-NW-TFET structure, equipped with a 10-probe array. This notable sensitivity factor indicates the biosensor's capability to detect the target biomolecule precisely. Moreover, our methodology considers the non-uniform distribution of ionic charges at the interface between the electrolyte and the insulator to improve the sensitivity assessment. Additionally, we explored the influence of the electrolyte's pH on the biosensor's sensitivity, considering the practical importance of pH variations in real-world scenarios.