SonicPlex: Simultaneous Arrangement of Massive Particles through a Simple Acoustic Micromanipulation Platform

The utilization of sound waves for the precise arrangement of particles and cells represents a significant advancement in the field of micromanipulation. Acoustic tweezers, based on surface acoustic waves, offer a non-invasive and non-contact approach, showcasing immense potential in biology and medicine. In comparison to conventional micromanipulation tools like optical and magnetic tweezers, acoustic tweezers exhibit distinct advantages in simultaneously manipulating a large number of particles. In this study, we employ piezoelectric ceramics to convert electrical signals from a generator into sound waves, enabling the manipulation of particles. Through experimental investigations, we explore the influence of input voltage, and input frequency on particle cluster spacing and aggregation levels. The outcomes of this research provide a simple and convenient operational platform for further cell micromanipulation and subsequent high-throughput screening of particles or cells.