Involvement of miR 155 in vascular calcifications

Vascular calcifications complicate endovascular and surgical treatment of arterial lesions. To date, there is no treatment that targets their development. Vascular calcifications are characterized by transdifferentiation of vascular smooth muscle cells (VSMCs) to an osteoblastic phenotype resulting in the formation of mineralized tissue, particularly within atherosclerotic plaques. The aim was to identify regulated miRNAs (miRs) in calcified arteries and test their role in VSMCs mineralization.