Serum metabolomic profiling unveils distinct sex-related metabolic patterns in NAFLD.

Charalambos Fotakis,Ioanna-Panagiota Kalafati,Athina I Amanatidou, Vasiliki Andreou, Manolis Matzapetakis,Maria Kafyra,Iraklis Varlamis,Maria Zervou,George V Dedoussis

Frontiers in endocrinology（2023）

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摘要

Results of this study aspire to address the paucity of data on sex differences regarding NAFLD pathogenesis. Targeted circulatory metabolome measurements could be used as diagnostic markers for the distinct stages of NAFLD in each sex and eventually aid in the development of novel sex-related therapeutic options.

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关键词

NMR metabolomics, NAFLD, serum metabolite markers, amino acids, sex, ketone bodies, glycine neurotransmitter, adolescent obesity

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