Cytochrome P450 activity in rheumatoid arthritis patients during continuous IL-6 receptor antagonist therapy.

Ann-Cathrine Dalgård Dunvald,Kasper Søltoft,Ekta Sheetal,Søren Andreas Just,Ida Emilie Brejning Frederiksen,Flemming Nielsen,Dorte Aalund Olsen,Jonna Skov Madsen,Oliver Hendricks,Tore Bjerregaard Stage

European journal of clinical pharmacology（2023）

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摘要

Based on sparse data from three patients, continuous anti-IL-6R therapy seems to cause an acute but transient increase in CYP3A4 activity in rheumatoid arthritis patients, which may be due to a normalization of the inflammation-suppressed CYP activity. Further studies are warranted to understand the mechanism behind this putative transient effect. Trial registration Registered in the ClinicalTrials.gov database (identifier NCT04842981) on April 13th, 2021.

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关键词

Rheumatoid arthritis, Drug-disease-drug interactions, IL-6 receptor antagonist, Inflammation

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