AI-Enabled Solutions, Explainability and Ethical Concerns for Predicting Sepsis in ICUs: A Systematic Review.

Artificial Intelligence (AI) advances are pushing the boundaries across research domains with AI-driven solutions in healthcare claiming a significant share. A key objective of these studies concerns the timely prediction of various pathological conditions. Sepsis is a life-threatening syndrome and one of the main causes of death in intensive care unit (ICU) patients. As it becomes a major health problem worldwide, sepsis early prediction could assist healthcare professionals towards making informed clinical decisions, and thereby, significantly reducing the sepsis' morbidity and mortality. A notable body of literature involving the use of AI for sepsis prediction exists. However, to the best of our knowledge, only a handful of studies focus on performing a systematic review of the AI enabled solutions for sepsis prediction in ICUs. In this context, the present paper aims to identify knowledge gaps, stimulate interest and yield motivations for future research. Moreover, to discuss ethical and explainability aspects and associated challenges. The literature search was conducted between February 2023 and April 2023 and considered eligible articles published within the last five years.