In vivo Pharmacokinetic/Pharmacodynamic Analysis of the Efficacy of the Cefepime/Nacubactam Combination Against β-Lactamase-Producing Enterobacterales based on the Instantaneous MIC Concept.

Yuki Igarashi,Wataru Takemura,Xiaoxi Liu,Nana Kojima,Takumi Morita,Victor Tuan Giam Chuang,Yuki Enoki,Kazuaki Taguchi,Kazuaki Matsumoto

Pharmaceutical research（2023）

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摘要

Our results indicate that fT > MIC is a PK/PD parameter is suitable for monitoring the CFPM/NAC combination. The minimum target value for achieving a static effect against β-lactamase-producing Enterobacterales is 30%.

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关键词

antimicrobial resistance,in vivo PK/PD study,instantaneous MIC,nacubactam,β-lactam/β-lactamase inhibitor

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