Ibrutinib directly reduces CD8+T cell exhaustion independent of BTK.

Frontiers in immunology（2023）

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摘要

Our study demonstrates that ibrutinib directly ameliorates CTL exhaustion, and provides evidence for its synergistic use with cancer immunotherapy.

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关键词

immune checkpoint blockade, T-cell exhaustion, ibrutinib, BTK inhibitor, CD8+T cells

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