Contribution of Lipoprotein(a) to Polygenic Risk Prediction of Coronary Artery Disease: A Prospective UK Biobank Analysis.

Hasanga D Manikpurage,Audrey Paulin,Arnaud Girard,Aida Eslami,Patrick Mathieu,Sébastien Thériault,Benoit J Arsenault

Circulation. Genomic and precision medicine（2023）

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摘要

Compared with individuals with a low genetic risk of CAD (low CAD-PRS and low Lp[a] levels), those with a high genetic risk (high CAD-PRS and high Lp[a] levels) had a 5-fold higher CAD risk. These results highlight a substantial contribution of genetic risk factors to CAD and that accurate estimation of genetic risk of CAD may need to consider blood levels of Lp(a).

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cardiovascular diseases, coronary artery disease, lipoprotein(a), myocardial infarction, polygenic risk score, primary prevention

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