Maternal IL-10 restricts fetal emergency myelopoiesis.

Amélie Collins,James W Swann, Melissa A Proven,Chandani M Patel,Carl A Mitchell,Monica Kasbekar,Paul V Dellorusso,Emmanuelle Passegué

bioRxiv : the preprint server for biology（2023）

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摘要

Fetal hematopoietic stem and progenitor cells are restricted from activating emergency myelopoiesis pathways by maternal IL-10, resulting in inadequate myeloid cell production in response to inflammatory challenges and contributing to neonatal neutropenia.

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fetal emergency myelopoiesis

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