No impact of polymorphism in the phosphodiesterase 5A gene in Cavalier King Charles Spaniels on pimobendan-induced inhibition of platelet aggregation response.

Maria J Reimann, Daniel N Faisst, Mads Knold,Kathryn M Meurs,Joshua A Stern,Signe E Cremer,Jacob E Møller,Ingrid Ljungvall,Jens Häggström,Lisbeth H Olsen

Journal of veterinary internal medicine（2023）

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摘要

The PDE5A:E90K polymorphism did not influence in vitro basal platelet aggregation response or the inhibitory effect of pimobendan on platelet aggregation in CKCS. Dogs with the PDE5A:E90K polymorphism did not appear to have altered platelet function or response to pimobendan treatment.

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关键词

dogs,genetic variation,heart disease,light transmission aggregometry,pharmacogenetics,platelet inhibition

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