Evaluating Tumor Hypoxia Radiosensitization Via Electron Paramagnetic Resonance Oxygen Imaging (EPROI).

Ashlyn G Rickard,Yvonne M Mowery,Alex Bassil,Douglas C Rouse,Nerissa T Williams,Theresa Charity,Rafaela Belloni,Brian Crouch,Nimmi Ramanujam,Daniel Stevenson,Rico Castillo,Stephanie Blocker,Boris Epel,Mrignayani Kotecha,Gregory M Palmer

Molecular imaging and biology（2023）

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摘要

EPROI provides 3D high-resolution pO quantification; EPR is better suited than DRS to characterize tumor hypoxia. PPV did not radiosensitize E0771 tumors nor p53/MCA sarcomas, which may be related to the complex pattern of vasculature in each tumor. Additionally, understanding model-dependent tumor hypoxia will provide a much-needed foundation for future therapeutic studies with hypoxic radiosensitizers.

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关键词

Electron paramagnetic resonance oxygen imaging (EPROI), Primary tumor model, Radiosensitizers, Diffuse reflectance spectroscopy (DRS), Tumor hypoxia, Preclinical tumor models

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