FRET-Amplified Singlet Oxygen Generation by Nanocomposites Comprising Ternary AgInS_2/ZnS Quantum Dots and Molecular Photosensitizers
arXiv (Cornell University)(2023)
摘要
Antibacterial photodynamic therapy (a-PDT) has emerged as a promising
non-invasive therapeutic modality that utilizes the combination of a
photosensitive agent, molecular oxygen, and excitation light to generate
reactive oxygen species (ROS), demonstrating remarkable activity against
multidrug-resistant bacterial infections. However, the effective use of
conventional photosensitizers is significantly limited by a number of their
shortcomings, namely, poor water solubility and low selectivity. Herein, we
present a novel biocompatible water-soluble nanocomposite based on hydrophobic
tetraphenylporphyrin (TPP) molecules and hydrophilic ternary AgInS_2/ZnS
quantum dots incorporated into a chitosan matrix as an improved photosensitizer
for a-PDT. We demonstrated that TPP molecules could be successfully transferred
into chitosan solution while remaining primarily in the form of monomers, which
are capable of singlet oxygen generation. We performed a detailed analysis of
the Förster resonance energy transfer (FRET) between quantum dots and TPP
molecules within the nanocomposite and proposed the mechanism of the singlet
oxygen efficiency enhancement via FRET.
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关键词
nanocomposites comprising
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