Changes in subcutaneous white adipose tissue cellular composition and molecular programs underlie glucose intolerance in persons with HIV.

Samuel S Bailin,Jonathan A Kropski,Rama D Gangula,LaToya Hannah,Joshua D Simmons,Mona Mashayekhi,Fei Ye,Run Fan,Simon Mallal,Christian M Warren,Spyros A Kalams,Curtis L Gabriel,Celestine N Wanjalla,John R Koethe

Frontiers in immunology（2023）

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摘要

These findings suggest a central role of tissue-resident immune cells in regulating SAT inflammation among PWH with metabolic disease, and underscore unique mechanisms that may converge to promote metabolic disease.

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关键词

human immunodeficiency virus, type 2 diabetes mellitus, white adipose tissue, subcutaneous adipose tissue, single-cell RNA sequencing, immune cells, glucose intolerance

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