Endonucleolytic RNA cleavage drives changes in gene expression during the innate immune response.

Agnes Karasik, Hernan A Lorenzi,Andrew V DePass,Nicholas R Guydosh

bioRxiv : the preprint server for biology（2023）

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摘要

Activated RNase L acts together with other dsRNA-sensing pathways to induce a strong immune response via JNK and p38 signalingGeneric RNA fragmentation plays a key role in inducing transcription, potentially through ribosome collisionsActivation of RNase L inhibits the effects of eIF2α phosphorylationTranslation of the antiviral IFIT mRNAs is inhibited by active RNase L.

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