Maternal exposure to sunlight-irradiated graphene oxide induces neurodegeneration-like symptoms in zebrafish offspring through intergenerational translocation and genomic DNA methylation alterations

Chaoxiu Ren,Ruyu Yan, Ziyi Yuan,Lijia Yin, Hongji Li,Jing Ding,Tao Wu,Rui Chen

Environment international（2023）

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摘要

•Sunlight changes the physicochemical properties of PEI-GO significantly.•Carbon atoms with unpaired electrons in defects of PEI-GO are oxidized in sunlight.•Maternal exposure to SL-PEI-GO induces neurodegeneration in offspring.•Sunlight irradiated PEI-GO can translocate from maternal zebrafish to offspring.•Ca2+-CaMKK-brsk2a pathway is activated by differential DNA methylation.

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关键词

Simulated sunlight irradiation,Intergenerational effects,Neurobehavioral disorders,genome-wide DNA methylation,Nanomaterials

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