Topological capture of mRNA for silencing gene expression.

Fangjie Lyu, Takashi Tomita,Naoko Abe,Haruka Hiraoka,Fumitaka Hashiya,Yuko Nakashima, Shiryu Kajihara,Fumiaki Tomoike,Zhaoma Shu,Kazumitsu Onizuka,Yasuaki Kimura,Hiroshi Abe

Chemical communications (Cambridge, England)（2023）

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摘要

We describe herein topological mRNA capture using branched oligodeoxynucleotides (ODNs) with multiple reactive functional groups. These fragmented ODNs efficiently formed topological complexes on template mRNA . In cell-based experiments targeting AcGFP mRNA, the bifurcated reactive ODNs showed a much larger gene silencing effect than the corresponding natural antisense ODN.

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关键词

mrna,topological capture,gene expression

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