The n3 Alpha-Linolenic Acid: A novel senolytic agent in endothelial cells

Background and Aims: Aging is a strong risk factor for atherosclerosis. Endothelial senescence leads to impaired angiogenesis, inflammation and oxidative stress, which are underlying pathological mechanisms of atherosclerosis. The omega-3 fatty acid (n-3 FA) α-linolenic acid (ALA) is known to reduce cardiovascular mortality and its benefits in the prevention of vascular aging are gradually emerging. We aimed to determine the senolytic effects and mechanisms of ALA on senescent endothelial cells.